(Sharecast News) - London's FTSE 100 was down 0.6% at 8,220.75 in afternoon trade on Tuesday.

Precious metals miner Fresnillo shone as FTSE 250 gold miner Centamin shot higher after it agreed to be taken over by AngloGold Ashanti in a £1.9bn deal.

Under the terms of the transaction, Centamin shareholders will receive 0.06983 new AngloGold Ashanti shares and $0.125 in cash. The price represents a premium of around 36.7% to the closing share price on Monday.

AstraZeneca was under the cosh, however, following mixed results from one of its key lung cancer trials.

Kathleen Brooks, research director at XTB, said the results "could make it difficult to get approval by the FDA in the US in the coming weeks".

FTSE 100 - Risers

JD Sports Fashion (JD.) 141.10p 3.86%

Unite Group (UTG) 975.50p 2.58%

Fresnillo (FRES) 514.50p 1.98%

Pershing Square Holdings Ltd NPV (PSH) 3,556.00p 1.43%

Land Securities Group (LAND) 660.50p 0.99%

Vistry Group (VTY) 1,357.00p 0.89%

LondonMetric Property (LMP) 204.00p 0.89%

Rentokil Initial (RTO) 476.00p 0.83%

F&C Investment Trust (FCIT) 1,006.00p 0.80%

CRH (CDI) (CRH) 6,442.00p 0.78%

FTSE 100 - Fallers

AstraZeneca (AZN) 12,240.00p -3.71%

Hikma Pharmaceuticals (HIK) 1,904.00p -2.06%

Croda International (CRDA) 3,903.00p -1.74%

B&M European Value Retail S.A. (DI) (BME) 417.30p -1.72%

Centrica (CNA) 120.40p -1.71%

Convatec Group (CTEC) 230.00p -1.54%

Melrose Industries (MRO) 465.10p -1.48%

Anglo American (AAL) 2,001.50p -1.38%

Smith (DS) (SMDS) 452.40p -1.22%

Pearson (PSON) 1,046.00p -1.18%